Another consideration when supplementing larger doses of Vitamin B6 as pyridoxine is the inhibiting effect on Pyridoxal-5-Phosphate, which is the natural form of Vitamin B6, so if amounts larger than 50 mg are taken per day, or if they are taken on an ongoing basis, the pills should also contain a small percentage as pyridoxal-5-phosphate to avoid the potential of causing neurological damage. However, regardless of the type, excessive intake of both - P5P or pyridoxine - when not needed, may lead to nerve and or spinal degeneration, so extra Vitamin B6 should be used with caution, or only by someone with an otherwise difficult-to-manage low magnesium high calcium ratio, and Mineral Ratios )... Full Text